


Bio Serum Probiotic Moisturizer
Skinara Bio Serum is more than a moisturizer—it’s a barrier therapy. This advanced formula pairs precision formulated ceramides with clinically proven topical probiotics, delivering a twofold approach to skin resilience.
- Ceramides are essential lipids that form the skin’s protective layer, sealing in moisture and shielding against environmental stressors.
- Probiotics help recalibrate the skin’s microbiome, reducing inflammation and stimulating natural ceramide production within the skin.
Together, they work synergistically to:
- Rebuild and reinforce the skin barrier repair
- Improve hydration and reduce transepidermal water loss
- Support long-term comfort for dry, sensitive, or eczema-prone skin
This dual-action system makes Bio Serum an ideal choice for those seeking the best fragrance-free moisturizer for skin barrier repair, microbiome balance, and clinical-grade hydration.
50 ml | 1.69 fl.oz
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Bio Serum Probiotic Moisturizer
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Let's get cellular
Sensitive skin isn’t just reactive—it’s biologically vulnerable. When the skin barrier breaks down, hydration escapes, irritants get in, and the microbiome falls out of balance.
Your skin is home to trillions of microbes that help regulate immunity, calm sensitivity, and keep moisture locked in. In healthy skin, good microbes thrive and protect you from the bad. But when the barrier is compromised, everything shifts.
Skinara® Bio Serum is designed to help restore that balance—based on skin microbiome lipid precursors, which act as the building blocks to allow the natural process of ceramide production to occur, supporting your skin’s natural defenses at the cellular and microbial level.
Sensitive skin care
Dermatologist Tested
Microbiome Friendly
Cruelty Free
Made with Organic Ingredients
Vegan Skincare
Skin Barrier Repair That Goes Deep
Microbiome Serum for Radiant Skin
It means the serum doesn’t just sit on the surface—it actively restores the skin’s protective layers from within. It supports lipid structure, strengthens cell cohesion, and boosts hydration at a molecular level, helping sensitive or compromised skin rebuild resilience over time.
Skin barrier repair serum
Bio Serum Probiotic Moisturizer is a microbiome supportive formula enriched with an advanced barrier lipid complex, including ceramides and biomimetic fatty acids. These clinically aligned lipids help restore and maintain a smooth, hydrated complexion while helping reinforce the skin’s natural barrier against environmental stressors and moisture loss.
Clinical grade hydration
Instead of layering different ingredients, that may or may not absorb, your microbiome becomes a living source. With the right probiotic strains, your microbiome acts like a smart factory—producing hydration, supporting skin repair barrier, and glow-boosters your skin needs to stay healthy. It’s care that comes from within.
Long term skin health
Imagine your skin not as a passive surface, but as a dynamic ecosystem—nurtured by beneficial microbes. Choosing the best multi Probiotic for skin health won’t just support your skin; it will produce what your skin craves—like ceramides, hydrators, and calming compounds. It’s not about adding more but activating what your skin already knows how to use.

Clinically Proven Probiotics
Skinara® Bio Serum Probiotic Moisturizer is a microbiome-friendly formula, including ceramides and biomimetic fatty acids. This blend of skin-identical lipids forms a protective film on the skin. From early-life the skin microbiome balance is important for barrier function and healthy maturation of the immune system.
How to Use Bio Serum
Simple steps for layering, frequency, and best results.

Micro Encapsulated
Skinara® precision probiotics stay protected until you activate them.
Inside Bio Serum, our multi probiotic for skin health are wrapped in Beautybiotic® microcapsules—tiny protective spheres that shield them from degradation. This keeps them fresh and potent until the moment of application.
As you massage Bio Serum into your skin using dampened fingers, the microcapsules break open, releasing active probiotics exactly where your skin needs them—at the surface and within the barrier. It’s targeted delivery, activated by touch.

Release Microscopic Friends
No guesswork. No contamination. Just gently massage the serum into your skin to release billions of living microscopic friends to release billions of living microscopic friends — fresh, potent, and ready to perform with precision, every time.

Replenish After Showering
Showering or bathing can strip away beneficial microbes and essential lipids that support your skin’s natural protection and barrier function. These skin natives help retain moisture and defend against irritation. Bio Serum Probiotic Moisturizer helps restore what’s lost to maintain deep hydration, balance and resilience.
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Your Questions Answered
FAQs about safety, results, and how Bio Serum fits into your routine.
→ Wondering if it’s safe for eczema? Curious about layering with other products? Our FAQ section covers everything from ingredient safety to usage tips—so you can feel confident in every drop.
What are the signs of damaged skin barrier?
A compromised skin barrier often develops subtly, making it easy to overlook until symptoms become more obvious. If you're experiencing skin sensitivity, dryness, or breakouts, these could be signs of damaged skin barrier. Understanding the signs of damaged skin barrier is crucial for restoring your skin health. And if you're noticing a few of these signs of damaged skin barrier, your skin might be crying out for a gentler routine and barrier-repairing skincare.
Key Signs of a Damaged Skin Barrier:
- A feeling of persistent dryness and tightness: your skin feels parched no matter how much moisturizer you apply.
- Redness and inflammation: especially after applying skincare products or being exposed to environmental stressors such as the sun, pollutants or smoking.
- Flakiness or rough texture: your skin may look patchy or feel uneven to the touch.
- Increased skin sensitivity: skincare or personal care products that never bothered you before start suddenly stinging or irritating your skin.
- Itchiness or discomfort: signs of a damaged skin barrier is when it’s struggling to protect you from external irritants.
- Breakouts or acne-like bumps: when your skin barrier is compromised, bad bacteria and pollutants can sneak in and take up residence.
- Shiny but dehydrated skin: sometimes your skin overproduces oil to try and compensate for lost moisture.
- Delayed healing: you notice that cuts, blemishes, or irritation take longer to recover than usual. This can be because your skin barrier can no longer heal as quickly because its damaged.
- Tightness after cleansing: especially if you’re using harsh soaps or exfolianting. These can further disrupt your skin barrier and worsen the situation.
If so, pause exfoliation and evaluate your skincare ingredients carefully. For personalized guidance, the Skinara Skin Analysis service can help you discover not only what to avoid—but also what your skin truly needs to feel calm and balanced and healthy.
How to repair skin barrier?
Your skin barrier is your body's first line of defense against environmental stressors while locking in moisture. The skin barrier isn’t just a physical shield though—it’s a dynamic ecosystem. Skin barrier repair involves restoring both its physical structure and biological balance. When compromised, it leads to dryness, sensitivity, and inflammation.
The fix? Restore lipids, calm inflammation, and rebalance your skin microbiome. Together, these elements support skin barrier repair by reinforcing microbial harmony and lipid integrity—especially vital for sensitive or pediatric skin. With consistent care, you'll see visible improvements within 7-20 days. As this is a biological process, the timeline depends on how disrupted your microbiome is to begin with.
How to choose the best probiotics for the skin?
Not all skin probiotics are created equal. Look for clinically studied strains, smart delivery systems, and water-free formulations. To ensure potency and efficacy:
- Avoid water-based probiotic products claiming “live cultures”—because moisture can rapidly degrade probiotic viability.
- Choose dry or encapsulated formulations that activate on contact with moist skin or dampened fingertips.
- Check for AFU (Active Fluorescent Units) or CFU (Colony Forming Units) counts—higher numbers suggest better microbial activity.
- Look for prebiotics or postbiotics (like inulin or lactobacillus ferment) to nourish native skin flora and enhance probiotic performance.
Pro tip: Skinara Skin Analysis service matches probiotic strains to your unique skin profile, supporting sensitivity, inflammation and skin barrier repair.
What's the difference between Pre Pro and Postbiotics?
Think of them as a team—each with a distinct role in restoring and maintaining your skin’s microbiome and barrier health. Not all “biotics” work the same way, but together they form a powerful system for resilience and repair:
• Probiotics are live, beneficial bacteria that actively support your skin’s microbiome. They help calm inflammation, balance pH, and reinforce the skin barrier—especially important for sensitive or reactive skin.
• Prebiotics are nutrients that selectively feed the good bacteria already living on your skin, encouraging a balanced and resilient microbial ecosystem.
• Postbiotics are bioactive compounds produced by probiotics—such as peptides, enzymes, and vitamins—that deliver targeted skin benefits without requiring live cultures. These ingredients derived from probiotics enhance hydration, reduce sensitivity, and accelerate skin barrier repair.
Together, they form a synergistic system called Symbiotics that mimics and amplifies the skin’s natural defenses—restoring balance, resilience, and clarity from the microbiome outward, plus as a bonus, make more use of the essential nutrients on your skin to create a stable environment in the long run.
How can I preserve the potency of probiotics in my skincare?
Probiotics are highly sensitive to water and lose potency when stored in aqueous solutions. That’s why it’s important to avoid products that claim live probiotic benefits but contain water. To preserve their activity, probiotic serums should only be activated at the time of application. Simply dampen your clean fingertips before use—this ensures optimal delivery directly to your skin, where they can thrive and support microbial balance.
How to keep probiotics alive?
Probiotics are delicate and they don’t stand a chance against harsh antibacterial preservatives like phenoxyethanol which can disrupt the microbial balance and destroy beneficial strains before they even reach your skin. At Skinara® we test the impact of preservatives. Skincare jars designed for finger dipping demand high levels of harsh preservatives that kill bacteria indiscriminately, wiping out both harmful microbes and beneficial probiotics. That’s why we don’t use them. We go beyond conventional preservation using microbiome-friendly formulations, avoid harsh preservatives and use specially designed airless dispensers that protect live cultures from contamination with maximum benefits for your skin.
Protecting your skin means protecting what keeps it alive.
How long do probiotics take to work?
Topical probiotics for the skin work by rebalancing your skin’s microbiome—but this isn’t a quick fix, it’s a biological process. The timeline depends on how disrupted your microbiome is to begin with. For meaningful results, we recommend using Skinara® Bio Serum Probiotic Moisturizer consistently, at least once daily, for a few weeks.
What are ceramides?
Ceramides are lipid molecules naturally found in the outermost layer of your skin, and a well-formulated ceramide serum is designed to replenish these vital lipids. Think of them as the structural glue that holds your skin cells together, forming the skin barrier film that protects against moisture loss, environmental stressors, and microbial imbalance. In skin barrier repair, ceramides play a critical role by helping:
• Reinforcing the lipid matrix that keeps your skin resilient and hydrated
• Locking in moisture to prevent transepidermal water loss
• Creating a stable environment for beneficial microbes to thrive
• Improving absorption of nutrients, peptides, and active ingredients
A balanaced microbiome enhances ceramide function: A healthy microbiome supports the skin’s natural lipid metabolism, making ceramide synthesis more efficient.
Probiotics reduce inflammation: They calm the skin, allowing ceramides to help rebuild the barrier without interference from chronic irritation.
The ceramides and probiotics aren’t just compatible - they’re complementary allies in skin barrier repair. Ceramide serum rebuilds the structure, while probiotics activate and protect the environment that allows that structure to thrive. Together, they create a hydrated, resilient, and biologically balanced skin barrier.
What are the ingredients: INCI list?
Skinara Bio Serum Probiotic Moisturizer formula is based on microbiome science. It's a powerhouse blend of barrier-repairing ingredients, microbiome complex, and barrier lipid matrix—designed to help restore, protect and improve skin health.
• Proprietary Multi Strain Probiotics – support microbial balance and barrier function
• Postbiotics: Lactobacillus Ferment Lysate and Plankton Extract derived from microalage – deliver peptides and enzymes for repair
• Prebiotics: Inulin, Alpha-Glucan Oligosaccharide – nourish beneficial microbes
• Ceramides: Ceramide NP, AP, EOP – restore lipid matrix and moisture retention
• Barrier Support: Phytosphingosine, Cholesterol, high molecular weight Hyaluronic Acid, Glycerin, Shea Butter, Jojoba Oil, Sunflower & Sesame Oil
Bio Serum forms a moisture-retaining film, helping reduce TEWL (Trans Epidermal Water Loss), soothe irritation, while supporting skin surface beneficial microbes.
When should I apply topical probiotics for the skin?
Bio Serum Probiotic Moisturizer is suitable for daily use on the face, hands, and body—it can be used in place of your regular moisturizer. For optimal results, apply 1–2 times daily, adjusting frequency based on your skin’s condition and sensitivity. If layering with other products or makeup, allow at least 10 minutes for full absorption.
For pediatric use, gently apply a thin layer to affected areas as directed by your healthcare provider.
Do I need a mini fridge for skincare?
Not necessarily. While mini skincare fridges are popular they’re more of a luxury than a must-have.
Products That Benefit from Cool Storage:
• Probiotic skincare: Live cultures can be sensitive to heat. A cool, dark storage place helps preserve their potency.
• Vitamin C serums: These oxidize quickly—cool temps slow that process.
• Eye creams and gels: Chilling them can reduce puffiness and feel extra refreshing.
• Natural or preservative-free products: These may have shorter shelf lives and benefit from cooler storage
Pro tips: Look for dispensers sealed from fingers, air and contaminants that offer precise application in the most hygienic way.
Always store in a cool, dry place below 22ºC / 71.6ºF with the lid firmly on.
FAQs
Please read our FAQs page to find out more.
Who is Bio Serum best for?
Everyone with sensitive skin with barrier dysfunction. It also belongs to best skincare products for men. Adults and pediatric-safe, fragrance-free, and dermatologically tested. Bio Serum microbiome lipids are not just moisturizers—they’re skin structure builders. Whether you need to support sensitive skin, clinical repair, or proactive anti-aging, Bio Serum helps you achieve your goal with scientific precision.
Is it suitable for eczema?
Yes. It’s clinically validated for barrier repair and inflammation reduction in eczema-prone profiles. Supports recovery from eczema, barrier dysfunction and stressed skin after procedures to assist with faster recovery.
Is it suitable for acne or oily skin?
Yes. Our ingredients are selected for their non-comedogenic properties and can actually reduce sebum overproduction.
• Non-comedogenic (no pore blocking)
• Free from fragrance, essential oils, and drying alcohols
• Tested on sensitive skin profiles
• Formulated to minimize allergenicity and maximize barrier recovery.
Can Bio Serum be used in both day and night care?
Yes. Bio Serum provides barrier benefits. Pair with AgeScreen SPF in the morning and antioxidants serum AgeLess at night.
Scientific references
- Skin Barrier Function: The Interplay of Physical, Chemical, and Immunological Processes. P. Baker, 2023
- Interaction between the microbiota and the skin barrier in aging. YR Woo, 2024